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Peptide-targeted small-molecule drugs: peptidedrug conjugates Peptidedrug conjugates (PDCs) comprise three elements: a tumor-homing peptide, linker, and cytotoxic agent (Fig

These observations are more broadly relevant to drug discovery at peptide GPCRs for which ligand acylation is a valid approach to improve pharmacokinetics

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The residues were mixed with 20 L of 20 mM HCl, 60 L of the sodium borate buffer provided with the AccQ Tag Ultra Derivatization Kit, and 20 L of 0.3% (w/v) AccQ acetonitrile solution and heated at 50 C for 10 min to obtain their AccQ derivatives