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Published protocols also note pregnancy, known hypersensitivity to IGF-1 analogs, and pre-existing insulin resistance or diabetes as conditions requiring exclusion or enhanced monitoring in study design

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MTHFR variants like C677T can raise homocysteine and increase demand on the folate and B12 methylation pathway, but they do not by themselves cause deficiency

In one such study, a group of older women was monitored for four years, and it was found that consistently high blood sugar was linked to a higher risk of both mild memory issues and more serious maladies like dementia

"Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers"