first injection of semaglutide what to expect How Inject Semaglutide: A Step-by-Step Guide what to expect after first

Use a new needle and syringe each time to avoid the risk of infection

More than a third of people lost 10 percent or more of their starting body weight with GIP/GLP-1 RA 10 mg (39.2 percent) and 15 mg (37.7 percent), and a quarter of people lost 15 percent or more with the 15 mg dose

In people with pre-existing diabetic retinopathy, there is a risk of worsening, particularly when starting treatment, and appropriate monitoring is advised

At 3.5 days, about 0.58 half-lives have elapsed, so roughly 67% of the prior half-dose's peak is still circulating when the next injection goes in (0.5 raised to 3.5 over 6 is about 0.67)

This approach lets you confirm good tolerance before increasing the dose