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A 2024 Swedish study followed 3,249 MS patients for an average of 10.6 years and found that obesity was associated with: 3 43% higher risk of reaching EDSS 3 (moderate disability) 40% higher risk of reaching EDSS 4 (significant walking impairment) More rapid cognitive decline Higher MRI activity showing new brain lesions A German study of 1,066 MS patients found even more striking results: obese patients reached disability milestones nearly 50% faster than those with normal weight