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Direct antipermeability effects of AMIN-induced upregulation of cAMP on cellular contraction may also be important in protection against phosgene-induced lung injury

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doi: 10.1002/hep.22848 52

It is challenging to define all the dopamine-driven signaling cascades that are downstream of cAMP, Ca 2+ , and PLC , as dopamine receptors can activate a wide range of additional proteins and effectors, including the MAPKs extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAPK, and c-Jun N-terminal kinase (JNK)/stress-activated protein kinase, L-type calcium channels, Akt, and AMP-activated protein kinase (Welsh et al., 1998