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Here, we have utilized liver-specific overexpression of cation transport regulator homolog 1 ( Chac1 ), a recently identified intracellular GSH-degrading enzyme, to induce hepatic GSH depletion during MASLD progression

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Studies have shown that acetyl-L-carnitine has neuroprotective effects, making it a potential supplement for cognitive health and neurodegenerative conditions

Latter involves the B microspecies of reduced glutathione, and the corresponding E microspecies of glutathione disulfide and can be expressed in relation with the MNA + /MNAH system by the following equation: Note that the involvement of B necessitates the involvement of E (see Fig