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Starting dosage is 0.8 mg, which should be increased to 2.5 mg after at least 30 days and then to 5.5 mg after another 30 days

While iron chelators have demonstrated efficacy in treating transfusion-associated iron overload in thalassemia patients, their cardiovascular applications remain predominantly experimental (66)

Statements Author contributions XW and EV contributed equally to writing of the manuscript

Whether those benefits are sustained long-term, whether the safety profile holds up across larger and more diverse populations, and whether the drug-vs-biologic classification battle shapes patient access these are the questions that 2026's remaining TRIUMPH readouts will begin to answer

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