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Varying roles of this domain have been indicated, and according to the most recent results from Sinnema et al., the Zn finger ordinarily has a positive regulatory effect on the catalytic activity of PHD2

[DOI] [PubMed] [Google Scholar] Coelho DR, Palma FR, Paviani V, Bonini MG

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162,163 Simultaneously, the accumulated PARs at DNA break sites are required for the recruitment of DNA repairs, including XRCC1, DDB2, ALC1, RECQ1, CHD2, BRCA1, Ligase V, MRE11 and NBS1, to initiate DNA repair

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