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However, some individuals experience better tolerance when taken with food

Patients often experience enhanced tolerability through the gradual therapeutic introduction, with a notably reduced incidence of gastrointestinal side effects

The higher rates in the diabetes population likely reflect the baseline GI motility alterations common in type 2 diabetes (diabetic gastroparesis, autonomic neuropathy) and the potential for additive GI effects with concomitant metformin use

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It is also ideal for evening administration before a night's rest if you want to naturally stimulate hormone secretion