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However, the significance of tyrosine phosphorylation, to the activity of the SDH complex, was demonstrated when it was shown that blocking the activity of the mitochondrial tyrosine phosphatase, PTPMT1, results in hyperphosphorylation and activation of the SDH complex

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Humans have not reported this trend, so it is unclear whether to consider this a risk

Use a shared decision approach considering patient preference, cost, access, and risk of adverse effects