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In some research contexts, observations have included mild and transient tolerability-related effects such as: Headaches Nausea Stimulation-related observations Temporary injection-site irritation or localized skin-response variability Research conditions, concentration ranges, dosage ranges, hydration status, administration frequency, and protocol structure may influence tolerability observations across experimental settings

Possible side effects may include injection site redness, mild tenderness, temporary headache, fatigue, nausea, or localized irritation

The thing we have to keep in mind when treating b12 deficiency is that often times the symptoms have taken years to manifest and we may not see a noticeable change after 1-2 shots

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As youll likely appreciate, this can cause serious issues for surgeons and general anaesthetists