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This decline is linked to chronic fatigue, brain fog, and delayed recovery from exercise and illness

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The two core mechanism papers were retracted in April 2025 (PMID 22129598, retraction notice PMID 40312092

If the athlete wants to take a GLP-1, the biggest thing that we know to advise them on is to focus on their on-bike fueling and double their protein intake off the bike, says longtime cycling coach Frank Overton, who notes he sees more and more cyclists starting on a GLP-1 and failing to mention it to their coacheswhich can result in slipping power numbers