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Furthermore, TRZ has diverse pleiotropic effects, such as anti-inflammatory, antioxidant, and anti-atherosclerotic effects, thereby decreasing cardiovascular complications (Taktaz et al

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Importantly, tirzepatide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)