In pregnant rabbits given 0.2, 2, 22, 156, or 260 mcg/kg/day exenatide during fetal organogenesis, irregular fetal skeletal ossifications were observed at 2 mcg/kg/day, a dose yielding systemic exposure up to 12-times the human exposure from the MRHD of BYETTA based on AUC comparison
The findings could also push dementia drug research in new and fruitful directions
KKF, a source for health policy research, polling and news, in May 2024 released a poll that found 12% of adults said they had taken a GLP-1 agonist, with 6% saying they currently take the drug
Suda A, Umaru BA, Yamamoto Y, Shima H, Saiki Y, Pan Y, et al
Willard, F.S., et al., Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist