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180 The embryonic fibroblasts of CITED2 - / - mouse had defective proliferation, senescence-associated cellular morphology and increase in expression of cell growth inhibitors p16 INK4a , p19 ARF , and p15 INK4b

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Some continue indefinitely with maintenance protocols, others cycle on and off based on seasonal needs or life circumstances, and still others transition to preventive protocols with less frequent dosing after achieving desired benefits