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1,2,3 Many hypoglycemic agents have been evaluated for cardiovascular and kidney protection beyond their originally designed hypoglycemic effects

Epic Research, which uses claims from the Epic electronic medical records data warehouse, which has over 200 million patient records, has published research demonstrating that the GLP-1 medications lead to sustained weight loss outside of clinical trials

GLP-1 receptors are found in parts of the brain that regulate appetite and feelings of fullness

The included studies on exendin-4 exposure were all performed in mouse models ( In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )

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