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MTX treatment caused a prominent dilatation of tubules and degeneration in tubular cells, marked vascular and glomerular congestion, dilatation in Bowmans space and inflammatory cell infiltration in the interstitium (Fig

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Also, L-carnitine can decrease the cell apoptosis through inhibiting the activity of caspases, ameliorating oxidative stress, and enhancing antioxidant defense systems [49, 50]

Change in body weight (a) and food intake (b) of 47-wk old male DIO C57BL6/J mice treated daily s.c