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They work by mimicking a natural hormone called glucagon-like peptide-1, which is a hormone that regulates appetite, blood sugar, and satiety signals

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Most GLP-1 agonists do not require dose adjustment for mild to moderate renal impairment, though specific agents have varying recommendations for severe impairment

For a deep (really deep) dive into the research studies that show the mechanics and efficacy of GLP-1 medications for weight loss, this video from Harvard Medical School gives in depth answers