Most research studies ran for 812 weeks
Note that the TB-500 name has historically been applied both to the full 43-residue protein and, as documented by Ho and colleagues (J Chromatogr A, 2012), to preparations containing only the LKKTETQ heptapeptide
Oh J, Kim JY, Park S, Youn JC, Son NH, Shin DJ, Lee SH, Kang SM, Jee SH, Jang Y
Moreover, bacterial production of the dopamine metabolite (3,4-dihydroxyphenylacetic acid) is strongly linked with mental QoL, while -aminobutyric acid is associated with clinical depression
Important safety considerations : Do not give folic acid alone before correcting B12 deficiency, as this can precipitate or worsen neurological complications Hydroxocobalamin is generally well tolerated