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A meta-analysis combining all three studies confirmed ontamalimabs superiority over placebo in UC patients across multiple outcomes: clinical remission (RR = 2.17, 95% CI 1.42.32, p 1, while secondary outcomes include clinical response, endoscopic remission and improvement, histologic-endoscopic mucosal improvement, and quality of life measures using the IBDQ questionnaire, evaluated over a 52-week double-blind treatment period comprising 12 weeks induction and 40 weeks maintenance with optional 40-week open-label extension

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