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Similarly, hypoxia-inducible factor 1-alpha (HIF-1) upregulates the miR-23a/24 cluster, driving a metabolic shift toward glycolysis under hypoxic conditions and thereby accelerating cancer progression [112]
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Furthermore, GSH plays a key role in various physiological processes, including signal transduction, cell proliferation, and apoptosis regulation
Consequently, VRK2 expression emerges as a dual-function biomarker: its targeted inhibition shows therapeutic efficacy in VRK2-high malignancies, while its deficiency serves as a predictive indicator for metabolic-targeted interventions
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