The group of GPx enzymes, which play an irreplaceable role in the regulation of ROS homeostasis in vivo, has been thought to use GSH as a reducing agent to catalyze the reduction of H 2 O 2 or organic peroxides to generate water or corresponding alcohols, respectively [17]
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Based on the review of key role of ROS in the occurrence and development of breast cancer, it is inspired that the changed expression level of GPxs may achieve the therapeutic purpose after determining its clinical significance in breast cancer
The authors found that this COF-based Fe 2+ catalyst provided abundant active sites to locally activate a doxorubicin prodrug, while simultaneously releasing tumor-associated antigens (TAAs) and triggering ICD ( Figure 10B )

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