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In 2017, a novel ruthenium(II) complex ( Ru II -17 ) was published that, in addition to curcumin, contained the ligand 1,4,7-trithiacyclononane, used as a face-coating ligand instead of typical arene-based ligands

Each reflects the same underlying receptor signaling described earlier, but the specific findings and study methods differ by outcome area

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The clustering between specific biological and clinical features has been postulated to identify a theoretical dimension labelled immuno-metabolic depression (IMD) [2] (aligning with the Research Domain Criteria (RDoC) framework [52]