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doi: 10.1016/0098-2997(93)90002-U, PMID: [DOI] [PubMed] [Google Scholar] 41.Spanos C, Maldonado EM, Fisher CP, Leenutaphong P, Oviedo-Orta E, Windridge D, et al

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Limitations : As a case report with one patient (N=1 study), the findings are anecdotal and require corroboration through larger, controlled studies to establish broader applicability

In fact, although acetaminophen is primarily metabolized by the liver, it is also distributed and metabolized in the brain, affecting the balance between antioxidants and oxidative stressors in the brain (Vigo 2019)

Transdermal estrogen carries lower thrombotic risk than oral formulations and represents the preferred delivery method for women with additional risk factors