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However, they should not yet be interpreted as evidence of a direct therapeutic effect on depression or anxiety. The research came as a separate study found that women taking semaglutide for diabetes before they knew they were pregnant had a 84% higher relative risk of preterm birth, compared with those who did not take GLP-1 medication, while the risk was 70% higher with liraglutide

This suggests inhibition of vagal cholinergic input into the stomach with a concomitant increase in gastric volume, though the exact mechanism is not clear

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