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Yet two of the 315 teens in Olson-Kennedys study killed themselves after initiation of hormones, even though the researchers had screened out participants who were visibly distraught (e.g., suicidal, homicidal, exhibiting violent behavior) at the time of consent or the baseline [mental health data collection]. Olson-Kennedy and her colleagues did not see this as a reason to stop the study to figure out what went wrong

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The primary endpoint was to demonstrate non-inferiority (with a non-inferiority margin of 0.3%) of tirzepatide 10 mg or 15 mg, or both, compared to glargine in terms of the change in HbA1c from baseline to 52 weeks

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If you're considering stopping semaglutide entirely, evidence suggests the best candidates are those who have maintained consistent exercise habits (150+ minutes weekly), adopted sustainable lower-calorie eating patterns naturally (not through restriction), and show no signs of rapid appetite return during any prior dose reductions