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Conversely, overexpression of HNF4 in HNF4-negative SNU449 cells strongly induced the luciferase activities from reporters containing the consensus (WT) HNF4 binding sites of MAT1A , BHMT , or CBS promoters, but this induction was significantly reduced when the binding sites were mutated (Mut) (Supplementary Fig

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Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4