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The deeper mechanism: during significant weight loss on semaglutide, hepatocytes (liver cells) process stored triglycerides at an accelerated rate

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In many situations, yes

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In the SURMOUNT-1 trial, participants on the highest dose of tirzepatide lost an average of 22.5 percent of their body weight at 72 weeks (Jastreboff et al., NEJM , 2022), compared to roughly 15 percent with semaglutide 2.4 mg in the STEP 1 trial (Wilding et al., NEJM , 2021)