Store the medication away from the cooling element so it doesn't freeze, and take the pen out of the fridge about 30 minutes before you use it to avoid the discomfort of a cold needle ( brrr )
Long-term intake of a high protein diet modulates liver steatosis and fat accumulation in OVX mice
No severe or confirmed hypoglycaemic episodes were reported in the two trials and there were no clinically relevant observations related to vital signs, physical examination, electrocardiogram or laboratory safety parameters, except temporary asymptomatic increases in lipase levels in two subjects at follow-up in the dosing conditions trial (from 46 U/L at screening to 231 U/L at follow-up and from 59 U/L at screening to 378 U/L at follow-up [normal range 1360 U/L])
Accessed December 26, 2023.
In addition, GLP-1RA therapy has been associated with favorable shifts in gut microbiota composition, including enrichment of short-chain fatty acid-producing bacteria, which promote Treg activity and suppress pro-inflammatory Th17 responses [43,44]