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Similar to other antioxidants, NAC may exhibit pro-oxidant actions, but these are generally limited to higher doses of 5501500 mg/kg/day [117,118,119]

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Depletion of GSH and therapeutic implications The depletion of GSH levels has been demonstrated in aging and multiple chronic degenerative diseases, including neurodegenerative, cardiovascular, pulmonary, immune disorders and cancers ( For this reason, many studies have been conducted on the best methods to increase intracellular and intramitochondrial levels of GSH

Cui J, Ren S, Sun B et al (2018) Optimization protocols and improved strategies for metal-organic frameworks for immobilizing enzymes: current development and future challenges

Testosterone deficiency in sickle cell disease: recognition and remediation