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Insulin glargine was given to female rats before mating, during mating, and throughout pregnancy at doses up to 0.36 mg/kg/day, which is approximately 50 times the recommended human subcutaneous starting dosage of 0.2 Units/kg/day (0.007 mg/kg/day)

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Clinical data shows patients who discontinue treatment regain approximately two-thirds of previous weight loss within 12 months

Unlike melatonin, which mainly regulates sleep-wake timing, DSIP seems to impact sleep depth and quality