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Reasonable markers to track: waist circumference, weight, resting heart rate, sleep quality, and a basic liver panel (ALT, AST) before and after long cycles

The CV risk markers improved, but surrogate endpoints aren't SELECT

High doses should be avoided by people with bleeding disorders or those taking anticoagulants without medical supervision

Both retatrutide and tirzepatide are GLP-1 class medications developed by Eli Lilly, but they differ in receptor mechanism, FDA approval status, weight loss trial results, and availability

Many patients notice stronger hunger reduction and increased satiety during the first 48 to 72 hours after injectionprecisely when plasma levels are climbing toward their maximum