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10.2147/jir.S249363 99 LiaoY.LinX.LiJ.TanR.ZhongX.WangL

ADVERSE REACTIONS: As mentioned above, hepatotoxicity has occurred with kava use.[15] Urticaria has been reported following consumption of kava.[16] Kava overdose resulted in altered mental status and ataxia.[17] Reversible kava dermopathy characterized by a scaly eruption has been reported in heavy kava drinkers.[18] HERB-DRUG INTERACTIONS: Kava may have additive effects when administered concurrently with benzodiazepines.[19] Kava inhibits cytochrome P450 2E1, 1A2, and 2D6, and can affect the metabolism of drugs that are metabolized by these enzymes.[20-22] Kava may potentiate the sedative effects of anesthetics.[23] TAKE HOME POINTS For additional information, visit the Memorial Sloan-Kettering Cancer Center Integrative Medicine Service website, "About Herbs," at

Metabolite identification was performed by searching against libraries with different confidence levels