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7 Initiating and monitoring If adding a DPP-4 inhibitor to sulfonylurea, meglitinide or insulin therapy, consider whether a dose reduction of the sulfonylurea/meglitinide/insulin is needed to reduce hypoglycaemia risk

However, the next phase of translational research must now broaden its scope

Kawasaki Y, Zhang L, Cheng J-K, Ji R-R (2008) Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord

This implies that in a significant number of PD patients there may be an underlying dysfunction in the bodys ability to detoxify