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The systematic analysis found that cartilage lesions complicated by limited progenitor cell activity and healing capacity, large size, high mechanical demands, local and systemic inflammation, or other systemic diseases are often excluded from treatment, likely due to complications and poor outcomes after cartilage restoration procedures in this context

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doi: 10.1186/1471-2407-9-56 [DOI] [PMC free article] [PubMed] [Google Scholar] 65.Cameron JC, Pakrasi HB

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If results are weak into the remodeling phase and starting dose was sub-3.2 mg, a dose increase and protocol modification may be warranted