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JAMA RCT)
[2] Patients should contact their GP if they experience: Side effects from B12 injections (though these are rare and usually mild) Difficulty attending scheduled injection appointments, as missed doses may lead to symptom recurrence New symptoms developing during treatment Concerns about treatment effectiveness or duration Changes in other medications that might affect B12 absorption Suspected adverse reactions to B12 treatment can be reported through the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)
He, L., Feng, D., Guo, H., Zhou, Y., & Li, Z
Human data remain limited to case reports, so efficacy in clinical practice is still under evaluation
Nicotinamide mononucleotide (NMN) was excluded from the dietary supplement definition by FDA in 2022-2023 and remains in regulatory limbo for new dietary supplement marketing in the US
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