[0065] Fmoc-PEG-OH, Fmoc-Glu(OH)-OtBu and octadecanedioic acid mono-tert-butyl ester were sequentially coupled by conventional amino acid coupling
For SPPS, every addition of an amino acid requires repeated washing steps, generating large volumes of hazardous solvent waste
15, the lower the purity of the intermediate, the more impurities are introduced into the intermediate or product, and particularly, the raw material Arg34GLP-1 (9-37) and the double-modified impurity which are difficult to remove are more easily obtained
By leveraging this mechanism, GLP-1 medications make you feel fuller sooner and longer after eating, which can lead to reduced calorie intake and subsequent weight loss
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