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Healthcare providers should consider this limited evidence base when making treatment decisions and should discuss these limitations with patients

They also point out that the full uACR improvement seemed to occur before the maximal effect on body weight was achieved. They made what, to me, is an odd claim that four weeks after discontinuation of semaglutide, body weight only modestly increased. In fact, even though this drug has a long half life, between weeks 24 and 28 the median weight returned to the same level seen at around 21 weeks, meaning the average weight regain was three weeks of weight loss over four weeks, with the drug at least somewhat still in their systems

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