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Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models
This feature renders cancer cells more sensitive to external stimuli that further increase the production of ROS 145,146,147 , and, as schematically summarized in Table 1, an increasing number of therapeutic strategies are being developed to elevate ROS levels to overwhelm the redox adaptation of the same cells, inducing oxidative stress incompatible with cellular life 148,149,150,151 (Fig
Incomplete resection often results in an increased rate of tumor recurrence
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