For example, TLK-286 (Telcyta, canfosfamide) was identified as the lead candidate in a rationally designed series of selectively toxic glutathione analogues (Lyttle et al, 1994), which continues to be evaluated both as a single agent and in combination chemotherapy in phase II and III clinical trials in ovarian cancer and other solid tumours
Individuals deficient in MPO have an increased risk of infections and inflammatory diseases
10.1038/s41467-019-09277-9 Summary Keywords amino acids (AAs), metabolism, cancer, mTORC (mammalian target of rapamycin kinase complex), epigenetic, tumor immunity, ferroptosis, tumor growth Citation Wei Z, Liu X, Cheng C, Yu W and Yi P (2021) Metabolism of Amino Acids in Cancer
Its angiogenic and anti-inflammatory effects make it uniquely effective for structural injuries
Fish Shellfish Immunol 60:219236 Parvathy AJ, Das BC, Jifiriya MJ, Varghese T, Pillai D, Rejish Kumar VJ (2023) Ammonia induced toxico-physiological responses in fish and management interventions