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But when you came up with this drug, because this was certainly one of your great contributions, this drug was just a step along the way in this kind of iterative process, wouldn't you say

doi: 10.1084/jem.20042031 136 BannenbergGLChiangNArielAAritaMTjonahenEGotlingerKHet al

IGF-1 LR3 combines the best of both approaches: an N-terminal extension of 13 arginine-rich residues for steric IGFBP hindrance, Arg3 substitution to definitively abolish BP3 and BP5 binding, and retention of the 70 IGF-1 residues to maintain IGF-1R recognition

Existing compounders would be known as 503A pharmacies and continue to operate under less rigorous safety standards, as long as they served individual patients

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