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Excessive consumption of high-calorie foods rich in fatty acids and trans fat leads to the accumulation of fatty acids and liposoluble toxins in the testicular environment, affecting spermatogenesis and testosterone production in Leydig cells (57)

Furthermore, the GCGR may play a role in renal energy metabolism, and GLP-1R/GCGR dual agonists such as 1907B have shown superior efficacy to GLP-1R single agonists in murine DN models, more effectively reducing proteinuria and improving renal function [232]