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For MCI patient samples, the Petersen criteria [70] were commonly used to diagnose MCI, though other studies used revised Petersen criteria [71], or a combination of the Montreal Cognitive Assessment, DSM-IV, Clinical Dementia Rating, and Mini-Mental State Examination [34, 62]

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In locus coeruleus neurons, cellular tolerance can be observed in brain slices prepared from animals treated with morphine for 3 days (Bailey et al., 2009a) and is reversed by administration of a PKC inhibitor