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Phase 2 Trial Results: Weight Loss Outcomes in Type 2 Diabetes At the highest 12 mg dose, adults with type 2 diabetes achieved approximately 16.9% mean body weight reduction from baseline at 24 weeks in a randomised, placebo-controlled phase 2 trial published in The Lancet (2023)

For vitamin B12 deficiency, injecting the vitamin into the muscle is recommended if the deficiency is severe

In a randomized controlled trial, the GLP-1R agonist exenatide showed reduced alcohol intake in a subgroup of people with both obesity and alcohol use disorder

(4) Changes in prescribing trends have been facilitated by a growing number of available GLP-1 receptor agonists, with currently ten agents approved for clinical use

Tirzepatide itself has not been shown to cause direct nephrotoxicity