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Abstract Purpose Chronic kidney disease (CKD) is one of the most common complications of type 2 diabetes (T2D), and CKD-related disability and mortality are increasing despite the recent advances in diabetes management

Affected neurons exhibit mitochondrial membrane potential loss, resulting in microtubule network disintegration and impaired autophagic flux toward lysosomes ( Mitochondrial dysfunction also contributes to tau pathology by increasing oligomer levels and shifting the monomeroligomer balance toward toxic oligomers (Weidling et al., 2020)

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It's also being studied for fatty liver disease (NASH) and cardiovascular outcomes