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Aggressive force can shear molecular bonds and reduce potency

Dehydration exacerbates nausea, causes headaches (often misattributed to the peptide itself), and can lead to dizziness and lightheadedness

Its activity can be reduced in physiological conditions, it is susceptible to proteolytic degradation, and it can exhibit cytotoxicity at high concentrations

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in 2017, it has been the subject of approximately 15-20 peer-reviewed publications spanning metabolic disease, muscle biology, cardiovascular research, neurodegenerative disease, and cancer metabolism