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(e) Impact of environmental stress and diseases Aging, neurodegeneration (e.g., Alzheimer's disease), and inflammation induce epigenetic reprogramming in microglia, leading to subpopulations with pro-inflammatory or neuroprotective phenotypes (Gosselin et al., 2017

Furthermore, estrogen has been observed to downregulate HIF-1 expression in the genioglossus muscle of CIH-exposed rats, thereby improving the endurance of upper airway muscles (68)