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These compounds, often present in low concentrations in commonly consumed foods like fruits, vegetables, spices, and fermented products 2,3,4,24 , extend the concept of hormesis beyond synthetic chemicals

The differences between tirzepatide and retatrutide include mechanisms that may differently affect hormonal metabolism, but these interactions have not yet been studied in the context of HRT

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Altogether, extrapolating preclinical findings directly to a human setting is premature without further investigations