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Kalluri, R., & Weinberg, R

N Engl J Med 389(6):514526 Rosenstock J, Frias J, Jastreboff AM, Du Y, Lou J, Gurbuz S et al (2023) Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA

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Formulations increasingly combine glutathione with complementary actives like niacinamide, vitamin C, and peptides to target multiple skin concerns simultaneously hyperpigmentation, fine lines, and uneven texture

Skin tightening goals might benefit from moderate concentrations (1% to 2%) used consistently over extended periods, allowing gradual collagen remodeling