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In vivo studies using diabetic mice and in vitro experiments demonstrate that canagliflozin boosts the expression of CPT1A , making FAO more efficient and relieving stress (Gan et al., 2024)

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Healthy cells do not lean on the FOXO4-p53 link for survival, which is why the effect is reported as selective for senescent cells

The current study draws attention to a third aspect of the thymic peptide effect that has not been clarified yet, wherein ubiquitous and highly abundant intranuclear precursors of so called thymic peptides play a fundamental role in all somatic cells